3HR1
Discovery of novel inhibitors of PDE10A
3HR1 の概要
エントリーDOI | 10.2210/pdb3hr1/pdb |
関連するPDBエントリー | 3HQW 3HQY 3HQZ |
分子名称 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A, SULFATE ION, 2-{[4-(1-methyl-4-pyridin-4-yl-1H-pyrazol-3-yl)phenoxy]methyl}quinoline, ... (6 entities in total) |
機能のキーワード | phosphodiesterase 10a, pde 10a, pde10 inhibitors, allosteric enzyme, alternative splicing, camp, camp-binding, cgmp, cgmp-binding, cytoplasm, hydrolase, magnesium, metal-binding, nucleotide-binding, zinc, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
由来する生物種 | Rattus norvegicus (rat) |
細胞内の位置 | Cytoplasm: Q9QYJ6 |
タンパク質・核酸の鎖数 | 1 |
化学式量合計 | 44340.28 |
構造登録者 | |
主引用文献 | Verhoest, P.R.,Chapin, D.S.,Corman, M.,Fonseca, K.,Harms, J.F.,Hou, X.,Marr, E.S.,Menniti, F.S.,Nelson, F.,O'Connor, R.,Pandit, J.,Proulx-Lafrance, C.,Schmidt, A.W.,Schmidt, C.J.,Suiciak, J.A.,Liras, S. Discovery of a Novel Class of Phosphodiesterase 10A Inhibitors and Identification of Clinical Candidate 2-[4-(1-Methyl-4-pyridin-4-yl-1H-pyrazol-3-yl)-phenoxymethyl]-quinoline (PF-2545920) for the Treatment of Schizophrenia J.Med.Chem., 52:5188-5196, 2009 Cited by PubMed: 19630403DOI: 10.1021/jm900521k 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (1.53 Å) |
構造検証レポート
検証レポート(詳細版)をダウンロード