3HPT
Crystal structure of human FxA in complex with (S)-2-cyano-1-(2-methylbenzofuran-5-yl)-3-(2-oxo-1-(2-oxo-2-(pyrrolidin-1-yl)ethyl)azepan-3-yl)guanidine
3HPT の概要
エントリーDOI | 10.2210/pdb3hpt/pdb |
分子名称 | Coagulation factor X, GLYCEROL, 1-cyano-2-(2-methyl-1-benzofuran-5-yl)-3-[(3S)-2-oxo-1-(2-oxo-2-pyrrolidin-1-ylethyl)azepan-3-yl]guanidine, ... (10 entities in total) |
機能のキーワード | serine protease, hydrolase, epidermal growth factor like domain, blood coagulation factor, cleavage on pair of basic residues, egf-like domain, gamma-carboxyglutamic acid, glycoprotein, hydroxylation, zymogen, blood clotting, blood coagulation, disulfide bond, protease, secreted |
由来する生物種 | Homo sapiens (human) 詳細 |
細胞内の位置 | Secreted: P00742 P00742 |
タンパク質・核酸の鎖数 | 4 |
化学式量合計 | 76648.65 |
構造登録者 | |
主引用文献 | Shi, Y.,Zhang, J.,Shi, M.,O'Connor, S.P.,Bisaha, S.N.,Li, C.,Sitkoff, D.,Pudzianowski, A.T.,Chong, S.,Klei, H.E.,Kish, K.,Yanchunas, J.,Liu, E.C.,Hartl, K.S.,Seiler, S.M.,Steinbacher, T.E.,Schumacher, W.A.,Atwal, K.S.,Stein, P.D. Cyanoguanidine-based lactam derivatives as a novel class of orally bioavailable factor Xa inhibitors. Bioorg.Med.Chem.Lett., 19:4034-4041, 2009 Cited by PubMed: 19541481DOI: 10.1016/j.bmcl.2009.06.014 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (2.19 Å) |
構造検証レポート
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