3HOR
Structure of the actin-binding domain of human filamin A (reduced)
Summary for 3HOR
| Entry DOI | 10.2210/pdb3hor/pdb |
| Related | 3HOC 3HOP |
| Descriptor | Filamin-A, PHOSPHATE ION (3 entities in total) |
| Functional Keywords | calponin homology domain, actin binding domain, acetylation, actin-binding, alternative splicing, cytoplasm, cytoskeleton, disease mutation, phosphoprotein, polymorphism, structural protein |
| Biological source | Homo sapiens (human) |
| Cellular location | Cytoplasm, cell cortex: P21333 |
| Total number of polymer chains | 2 |
| Total formula weight | 61385.22 |
| Authors | Clark, A.R.,Sawyer, G.M.,Robertson, S.P.,Sutherland-Smith, A.J. (deposition date: 2009-06-03, release date: 2009-10-13, Last modification date: 2023-11-01) |
| Primary citation | Clark, A.R.,Sawyer, G.M.,Robertson, S.P.,Sutherland-Smith, A.J. Skeletal dysplasias due to filamin A mutations result from a gain-of-function mechanism distinct from allelic neurological disorders Hum.Mol.Genet., 18:4791-4800, 2009 Cited by PubMed: 19773341DOI: 10.1093/hmg/ddp442 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.7 Å) |
Structure validation
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