3HO9

Structure of E.coli FabF(C163A) in complex with Platencin A1

3HO9 の概要

• エントリーDOI: 10.2210/pdb3ho9/pdb
• 関連するPDBエントリー: 3HNZ 3HO2
• 分子名称: 3-oxoacyl-[acyl-carrier-protein] synthase 2, 2,4-dihydroxy-3-({3-[(2R,4aR,8S,8aR,9R)-9-hydroxy-8-methyl-3-methylidene-7-oxo-1,3,4,7,8,8a-hexahydro-2H-2,4a-ethanonap hthalen-8-yl]propanoyl}amino)benzoic acid (3 entities in total)
• 機能のキーワード: fabf, platensimycin, platencin a1, kas2, acyltransferase, fatty acid biosynthesis, lipid synthesis, transferase
• 由来する生物種: Escherichia coli
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 45046.71

構造登録者

Soisson, S.M.,Parthasarathy, G. (登録日: 2009-06-01, 公開日: 2010-02-09, 最終更新日: 2023-09-06)

主引用文献

Singh, S.B.,Ondeyka, J.G.,Herath, K.B.,Zhang, C.,Jayasuriya, H.,Zink, D.L.,Parthasarathy, G.,Becker, J.W.,Wang, J.,Soisson, S.M.
Isolation, enzyme-bound structure and antibacterial activity of platencin A1 from Streptomyces platensis.
Bioorg.Med.Chem.Lett., 19:4756-4759, 2009

PubMed Abstract: Natural products continue to serve as one of the best sources for discovery of antibacterial agents as exemplified by the recent discoveries of platensimycin and platencin. Chemical modifications as well as discovery of congeners are the main sources for gaining knowledge of structure-activity relationship of natural products. Screening for congeners in the extracts of the fermentation broths of Streptomyces platensis led to the isolation of platencin A(1), a hydroxy congener of platencin. The hydroxylation of the tricyclic enone moiety negatively affected the antibacterial activity and appears to be consistent with the hydrophobic binding pocket of the FabF. Isolation, structure, enzyme-bound structure and activity of platencin A(1) and two other congeners have been described.

PubMed: 19581087
DOI: 10.1016/j.bmcl.2009.06.061

実験手法

X-RAY DIFFRACTION (1.9 Å)