3HL7

Crystal Structure of Human p38alpha complexed with SD-0006

3HL7 の概要

• エントリーDOI: 10.2210/pdb3hl7/pdb
• 関連するPDBエントリー: 3HLL
• 分子名称: Mitogen-activated protein kinase 14, 2-{4-[5-(4-chlorophenyl)-4-pyrimidin-4-yl-1H-pyrazol-3-yl]piperidin-1-yl}-2-oxoethanol, 2-fluoro-4-[4-(4-fluorophenyl)-1H-pyrazol-3-yl]pyridine, ... (4 entities in total)
• 機能のキーワード: atp-binding, kinase, nucleotide-binding, nucleus, phosphoprotein, serine/threonine-protein kinase, transferase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm : Q16539
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 41998.29

構造登録者

Shieh, H.-S.,Kurumbail, R.G.,Stegeman, R.A.,Williams, J.M. (登録日: 2009-05-26, 公開日: 2009-07-14, 最終更新日: 2024-02-21)

• 主引用文献: Xing, L.,Shieh, H.S.,Selness, S.R.,Devraj, R.V.,Walker, J.K.,Devadas, B.,Hope, H.R.,Compton, R.P.,Schindler, J.F.,Hirsch, J.L.,Benson, A.G.,Kurumbail, R.G.,Stegeman, R.A.,Williams, J.M.,Broadus, R.M.,Walden, Z.,Monahan, J.B.; Structural bioinformatics-based prediction of exceptional selectivity of p38 MAP kinase inhibitor PH-797804.; Biochemistry, 48:6402-6411, 2009; PubMed: 19496616; DOI: 10.1021/bi900655f

実験手法

X-RAY DIFFRACTION (1.88 Å)