3HKN

Human carbonic anhydrase II in complex with (2,3,4,6-Tetra-O-acetyl-beta-D-galactopyranosyl) -(1-4)-1,2,3,6-tetra-O-acetyl-1-thio-beta-D-glucopyranosylsulfonamide

Summary for 3HKN

Entry DOI	10.2210/pdb3hkn/pdb
Descriptor	Carbonic anhydrase 2, 2,3,4,6-tetra-O-acetyl-beta-D-galactopyranose-(1-4)-(1S)-2,3,6-tri-O-acetyl-1,5-anhydro-1-sulfamoyl-D-glucitol, ZINC ION, ... (5 entities in total)
Functional Keywords	carbonic anhydrase drug design, disease mutation, lyase, metal-binding
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	30238.29
Authors	Paul, B.,Poulsen, S.-A.,Hofmann, A. (deposition date: 2009-05-25, release date: 2009-10-13, Last modification date: 2024-02-21)
Primary citation	Lopez, M.,Paul, B.,Hofmann, A.,Morizzi, J.,Wu, Q.K.,Charman, S.A.,Innocenti, A.,Vullo, D.,Supuran, C.T.,Poulsen, S.A. S-glycosyl primary sulfonamides--a new structural class for selective inhibition of cancer-associated carbonic anhydrases. J.Med.Chem., 52:6421-6432, 2009 Cited by PubMed: 19827837 DOI: 10.1021/jm900914e PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation