3HFC

A trimeric form of the Kv7.1 A domain Tail, L602M/L606M mutant Semet

3HFC の概要

• エントリーDOI: 10.2210/pdb3hfc/pdb
• 関連するPDBエントリー: 3HFE
• 分子名称: Potassium voltage-gated channel subfamily KQT member 1 (2 entities in total)
• 機能のキーワード: coiled coil, trimer, alternative splicing, atrial fibrillation, cell membrane, cytoplasmic vesicle, deafness, disease mutation, glycoprotein, ion transport, ionic channel, long qt syndrome, membrane, phosphoprotein, polymorphism, potassium, potassium channel, potassium transport, short qt syndrome, transmembrane, transport, voltage-gated channel, transport protein
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cell membrane; Multi-pass membrane protein: P51787
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 10597.99

構造登録者

Xu, Q.,Minor, D.L. (登録日: 2009-05-11, 公開日: 2009-09-01, 最終更新日: 2021-10-13)

• 主引用文献: Xu, Q.,Minor, D.L.; Crystal structure of a trimeric form of the K(V)7.1 (KCNQ1) A-domain tail coiled-coil reveals structural plasticity and context dependent changes in a putative coiled-coil trimerization motif.; Protein Sci., 18:2100-2114, 2009; PubMed: 19693805; DOI: 10.1002/pro.224

実験手法

X-RAY DIFFRACTION (2.45 Å)