3HEC

P38 in complex with Imatinib

3HEC の概要

• エントリーDOI: 10.2210/pdb3hec/pdb
• 関連するPDBエントリー: 3HEG
• 分子名称: Mitogen-activated protein kinase 14, 4-(4-METHYL-PIPERAZIN-1-YLMETHYL)-N-[4-METHYL-3-(4-PYRIDIN-3-YL-PYRIMIDIN-2-YLAMINO)-PHENYL]-BENZAMIDE, octyl beta-D-glucopyranoside, ... (4 entities in total)
• 機能のキーワード: transferase, atp-binding, kinase, nucleotide-binding, nucleus, phosphoprotein, serine/threonine-protein kinase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 40691.67

構造登録者

Namboodiri, H.V.,Karpusas, M. (登録日: 2009-05-08, 公開日: 2009-11-10, 最終更新日: 2023-09-06)

• 主引用文献: Namboodiri, H.V.,Bukhtiyarova, M.,Ramcharan, J.,Karpusas, M.,Lee, Y.,Springman, E.B.; Analysis of imatinib and sorafenib binding to p38alpha compared with c-Abl and b-Raf provides structural insights for understanding the selectivity of inhibitors targeting the DFG-out form of protein kinases.; Biochemistry, 49:3611-3618, 2010; PubMed: 20337484; DOI: 10.1021/bi100070r

実験手法

X-RAY DIFFRACTION (2.5 Å)