3HAL
Crystal structure of Rabbit acidic fibroblast growth factor
Summary for 3HAL
| Entry DOI | 10.2210/pdb3hal/pdb |
| Related | 1JQZ |
| Descriptor | Fibroblast growth factor 1 isoform 1, SULFATE ION, CHLORIDE ION, ... (4 entities in total) |
| Functional Keywords | beta-trefoil, hormone |
| Biological source | Oryctolagus cuniculus (rabbit) |
| Total number of polymer chains | 2 |
| Total formula weight | 33474.25 |
| Authors | Blaber, M.,Lee, J. (deposition date: 2009-05-01, release date: 2009-12-22, Last modification date: 2023-09-06) |
| Primary citation | Lee, J.,Blaber, S.I.,Irsigler, A.,Aspinwall, E.,Blaber, M. X-ray structure and biophysical properties of rabbit fibroblast growth factor 1. Acta Crystallogr.,Sect.F, 65:1097-1104, 2009 Cited by PubMed Abstract: The rabbit is an important and de facto animal model in the study of ischemic disease and angiogenic therapy. Additionally, fibroblast growth factor 1 (FGF-1) is emerging as one of the most important growth factors for novel proangiogenic and pro-arteriogenic therapy. However, despite its significance, the fundamental biophysical properties of rabbit FGF-1, including its X-ray structure, have never been reported. Here, the cloning, crystallization, X-ray structure and determination of the biophysical properties of rabbit FGF-1 are described. The X-ray structure shows that the amino-acid differences between human and rabbit FGF-1 are solvent-exposed and therefore potentially immunogenic, while the biophysical studies identify differences in thermostability and receptor-binding affinity that distinguish rabbit FGF-1 from human FGF-1. PubMed: 19923726DOI: 10.1107/S1744309109040287 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
Download full validation report
