3HAL

Crystal structure of Rabbit acidic fibroblast growth factor

3HAL の概要

• エントリーDOI: 10.2210/pdb3hal/pdb
• 関連するPDBエントリー: 1JQZ
• 分子名称: Fibroblast growth factor 1 isoform 1, SULFATE ION, CHLORIDE ION, ... (4 entities in total)
• 機能のキーワード: beta-trefoil, hormone
• 由来する生物種: Oryctolagus cuniculus (rabbit)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 33474.25

構造登録者

Blaber, M.,Lee, J. (登録日: 2009-05-01, 公開日: 2009-12-22, 最終更新日: 2023-09-06)

主引用文献

Lee, J.,Blaber, S.I.,Irsigler, A.,Aspinwall, E.,Blaber, M.
X-ray structure and biophysical properties of rabbit fibroblast growth factor 1.
Acta Crystallogr.,Sect.F, 65:1097-1104, 2009

PubMed Abstract: The rabbit is an important and de facto animal model in the study of ischemic disease and angiogenic therapy. Additionally, fibroblast growth factor 1 (FGF-1) is emerging as one of the most important growth factors for novel proangiogenic and pro-arteriogenic therapy. However, despite its significance, the fundamental biophysical properties of rabbit FGF-1, including its X-ray structure, have never been reported. Here, the cloning, crystallization, X-ray structure and determination of the biophysical properties of rabbit FGF-1 are described. The X-ray structure shows that the amino-acid differences between human and rabbit FGF-1 are solvent-exposed and therefore potentially immunogenic, while the biophysical studies identify differences in thermostability and receptor-binding affinity that distinguish rabbit FGF-1 from human FGF-1.

PubMed: 19923726
DOI: 10.1107/S1744309109040287

実験手法

X-RAY DIFFRACTION (1.8 Å)