3H9F

Crystal Structure of Human Dual Specificity Protein Kinase (TTK) in complex with a pyrimido-diazepin ligand

3H9F の概要

• エントリーDOI: 10.2210/pdb3h9f/pdb
• 分子名称: Dual specificity protein kinase TTK, MAGNESIUM ION, 9-cyclopentyl-2-(4-(4-hydroxypiperidin-1-yl)-2-methoxyphenylamino)-5-methyl-8,9-dihydro-5H-pyrimido[4,5-b][1,4]diazepin -6(7H)-one, ... (4 entities in total)
• 機能のキーワード: ttk, hmps1, pyt, esk, kinase, dual specificity, phosphotyrosine picked threonine kinase, sgc, structural genomics consortium, atp-binding, nucleotide-binding, phosphoprotein, serine/threonine-protein kinase, transferase, tyrosine-protein kinase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 36870.38

構造登録者

Filippakopoulos, P.,Soundararajan, M.,Keates, T.,Elkins, J.M.,King, O.,Fedorov, O.,Picaud, S.S.,Pike, A.C.W.,Yue, W.,Chaikuad, A.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.,Weigelt, J.,Bountra, C.,Kwiatkowski, N.,Gray, N.S.,Knapp, S.,Structural Genomics Consortium (SGC) (登録日: 2009-04-30, 公開日: 2009-05-19, 最終更新日: 2023-09-06)

• 主引用文献: Kwiatkowski, N.,Jelluma, N.,Filippakopoulos, P.,Soundararajan, M.,Manak, M.S.,Kwon, M.,Choi, H.G.,Sim, T.,Deveraux, Q.L.,Rottmann, S.,Pellman, D.,Shah, J.V.,Kops, G.J.,Knapp, S.,Gray, N.S.; Small-molecule kinase inhibitors provide insight into Mps1 cell cycle function.; Nat.Chem.Biol., 6:359-368, 2010; PubMed: 20383151; DOI: 10.1038/nchembio.345

実験手法

X-RAY DIFFRACTION (2.6 Å)