3H7D
The crystal structure of the cathepsin K Variant M5 in complex with chondroitin-4-sulfate
Summary for 3H7D
Entry DOI | 10.2210/pdb3h7d/pdb |
Related | 3C9E |
Descriptor | Cathepsin K, 2-acetamido-2-deoxy-4-O-sulfo-beta-D-galactopyranose-(1-4)-beta-D-glucopyranuronic acid-(1-3)-2-acetamido-2-deoxy-4-O-sulfo-beta-D-galactopyranose-(1-4)-beta-D-glucopyranuronic acid-(1-3)-2-acetamido-2-deoxy-4-O-sulfo-beta-D-galactopyranose-(1-4)-beta-D-glucopyranuronic acid, CALCIUM ION, ... (5 entities in total) |
Functional Keywords | glycosaminoglycan, sulfhydryl peptidase, cathepsin k mutant, ternary complex, disease mutation, disulfide bond, glycoprotein, hydrolase, lysosome, protease, thiol protease, zymogen |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 49115.78 |
Authors | Cherney, M.M.,Kienetz, M.,Bromme, D.,James, M.N.G. (deposition date: 2009-04-24, release date: 2010-04-28, Last modification date: 2023-09-06) |
Primary citation | Cherney, M.M.,Lecaille, F.,Kienitz, M.,Nallaseth, F.S.,Li, Z.,James, M.N.,Bromme, D. Structure-activity analysis of cathepsin K/chondroitin 4-sulfate interactions. J.Biol.Chem., 286:8988-8998, 2011 Cited by PubMed: 21193413DOI: 10.1074/jbc.M110.126706 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.242 Å) |
Structure validation
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