3H7D

The crystal structure of the cathepsin K Variant M5 in complex with chondroitin-4-sulfate

3H7D の概要

• エントリーDOI: 10.2210/pdb3h7d/pdb
• 関連するPDBエントリー: 3C9E
• 分子名称: Cathepsin K, 2-acetamido-2-deoxy-4-O-sulfo-beta-D-galactopyranose-(1-4)-beta-D-glucopyranuronic acid-(1-3)-2-acetamido-2-deoxy-4-O-sulfo-beta-D-galactopyranose-(1-4)-beta-D-glucopyranuronic acid-(1-3)-2-acetamido-2-deoxy-4-O-sulfo-beta-D-galactopyranose-(1-4)-beta-D-glucopyranuronic acid, CALCIUM ION, ... (5 entities in total)
• 機能のキーワード: glycosaminoglycan, sulfhydryl peptidase, cathepsin k mutant, ternary complex, disease mutation, disulfide bond, glycoprotein, hydrolase, lysosome, protease, thiol protease, zymogen
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 49115.78

構造登録者

Cherney, M.M.,Kienetz, M.,Bromme, D.,James, M.N.G. (登録日: 2009-04-24, 公開日: 2010-04-28, 最終更新日: 2023-09-06)

• 主引用文献: Cherney, M.M.,Lecaille, F.,Kienitz, M.,Nallaseth, F.S.,Li, Z.,James, M.N.,Bromme, D.; Structure-activity analysis of cathepsin K/chondroitin 4-sulfate interactions.; J.Biol.Chem., 286:8988-8998, 2011; PubMed: 21193413; DOI: 10.1074/jbc.M110.126706

実験手法

X-RAY DIFFRACTION (2.242 Å)