3H5G

Switching the Chirality of the Metal Environment Alters the Coordination Mode in Designed Peptides.

3H5G の概要

• エントリーDOI: 10.2210/pdb3h5g/pdb
• 関連するPDBエントリー: 1coi 1cos 2jgo 3H5F
• 分子名称: COIL SER L16D-Pen, ZINC ION, ACETATE ION, ... (4 entities in total)
• 機能のキーワード: de-novo protein, parallel three-stranded coiled coil, d-penicillamine, de novo protein
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 10578.62

構造登録者

Peacock, A.F.A.,Stuckey, J.A.,Pecoraro, V.L. (登録日: 2009-04-22, 公開日: 2009-07-14, 最終更新日: 2023-11-22)

主引用文献

Peacock, A.F.,Stuckey, J.A.,Pecoraro, V.L.
Switching the Chirality of the Metal Environment Alters the Coordination Mode in Designed Peptides.
Angew.Chem.Int.Ed.Engl., 48:7371-7374, 2009

PubMed Abstract: The effects of switching the chirality of a single layer of amino acids in a three stranded coiled coil has been investigated. X-ray crystallography reveals that this modification is well tolerated and does not alter the designed structure. In contrast, spectroscopic studies of cadmium binding to both the L- and D- enantiomers of the penicillamine, provide evidence that this switch dramatically alters the metal binding capability, the resulting coordination environment and the position of binding.

PubMed: 19579245
DOI: 10.1002/anie.200902166

実験手法

X-RAY DIFFRACTION (1.71 Å)