3H3C
Crystal structure of PYK2 in complex with Sulfoximine-substituted trifluoromethylpyrimidine analog
3H3C の概要
エントリーDOI | 10.2210/pdb3h3c/pdb |
分子名称 | Protein tyrosine kinase 2 beta, SULFATE ION, 4-{[4-{[(1R,2R)-2-(dimethylamino)cyclopentyl]amino}-5-(trifluoromethyl)pyrimidin-2-yl]amino}-N-methylbenzenesulfonamide, ... (4 entities in total) |
機能のキーワード | pyk2, kinase, alternative splicing, atp-binding, cell membrane, cytoplasm, membrane, nucleotide-binding, phosphoprotein, polymorphism, transferase, tyrosine-protein kinase |
由来する生物種 | Homo sapiens (human) |
細胞内の位置 | Cytoplasm: Q14289 |
タンパク質・核酸の鎖数 | 1 |
化学式量合計 | 33129.14 |
構造登録者 | |
主引用文献 | Walker, D.P.,Zawistoski, M.P.,McGlynn, M.A.,Li, J.C.,Kung, D.W.,Bonnette, P.C.,Baumann, A.,Buckbinder, L.,Houser, J.A.,Boer, J.,Mistry, A.,Han, S.,Xing, L.,Guzman-Perez, A. Sulfoximine-substituted trifluoromethylpyrimidine analogs as inhibitors of proline-rich tyrosine kinase 2 (PYK2) show reduced hERG activity. Bioorg.Med.Chem.Lett., 19:3253-3258, 2009 Cited by PubMed: 19428251DOI: 10.1016/j.bmcl.2009.04.093 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (2 Å) |
構造検証レポート
検証レポート(詳細版)をダウンロード