3H0V

Human AdoMetDC with 5'-Deoxy-5'-(dimethylsulfonio) adenosine

3H0V の概要

• エントリーDOI: 10.2210/pdb3h0v/pdb
• 関連するPDBエントリー: 1I72 1I79 1I7B 1I7C 1I7M 1JEN 3H0W
• 分子名称: S-adenosylmethionine decarboxylase proenzyme, 1,4-DIAMINOBUTANE, 5'-deoxy-5'-(dimethyl-lambda~4~-sulfanyl)adenosine, ... (6 entities in total)
• 機能のキーワード: adometdc with competitive substrate analogs, autocatalytic cleavage, decarboxylase, lyase, phosphoprotein, polyamine biosynthesis, pyruvate, s-adenosyl-l-methionine, schiff base, spermidine biosynthesis, zymogen
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 38800.11

構造登録者

Bale, S.,Brooks, W.H.,Hanes, J.W.,Mahesan, A.M.,Guida, W.C.,Ealick, S.E. (登録日: 2009-04-10, 公開日: 2009-06-30, 最終更新日: 2023-11-15)

• 主引用文献: Bale, S.,Brooks, W.,Hanes, J.W.,Mahesan, A.M.,Guida, W.C.,Ealick, S.E.; Role of the sulfonium center in determining the ligand specificity of human s-adenosylmethionine decarboxylase.; Biochemistry, 48:6423-6430, 2009; PubMed: 19527050; DOI: 10.1021/bi900590m

実験手法

X-RAY DIFFRACTION (2.24 Å)