3H0Q

Crystal structure of the carboxyltransferase domain of acetyl-coenzyme A carboxylase in complex with compound 3

Summary for 3H0Q

• Entry DOI: 10.2210/pdb3h0q/pdb
• Related: 3H0J 3H0S
• Descriptor: Acetyl-CoA carboxylase, 4-({4-[(2-methylquinolin-6-yl)methyl]piperidin-1-yl}carbonyl)-2-phenylquinoline (3 entities in total)
• Functional Keywords: transferase, acetyl-coa carboxylase, carboxyltransferase, inhibitor, ligase
• Biological source: Saccharomyces cerevisiae (yeast)
• Cellular location: Cytoplasm: Q00955
• Total number of polymer chains: 3
• Total formula weight: 263128.71

Authors

Zhang, H.,Tong, L. (deposition date: 2009-04-10, release date: 2010-04-21, Last modification date: 2024-02-21)

• Primary citation: Corbett, J.W.,Freeman-Cook, K.D.,Elliott, R.,Vajdos, F.,Rajamohan, F.,Kohls, D.,Marr, E.,Zhang, H.,Tong, L.,Tu, M.,Murdande, S.,Doran, S.D.,Houser, J.A.,Song, W.,Jones, C.J.,Coffey, S.B.,Buzon, L.,Minich, M.L.,Dirico, K.J.,Tapley, S.,McPherson, R.K.,Sugarman, E.,Harwood, H.J.,Esler, W.; Discovery of small molecule isozyme non-specific inhibitors of mammalian acetyl-CoA carboxylase 1 and 2.; Bioorg.Med.Chem.Lett., 20:2383-2388, 2010; PubMed: 20219367; DOI: 10.1016/j.bmcl.2009.04.091

Experimental method

X-RAY DIFFRACTION (2.5 Å)