3H0Q

Crystal structure of the carboxyltransferase domain of acetyl-coenzyme A carboxylase in complex with compound 3

3H0Q の概要

• エントリーDOI: 10.2210/pdb3h0q/pdb
• 関連するPDBエントリー: 3H0J 3H0S
• 分子名称: Acetyl-CoA carboxylase, 4-({4-[(2-methylquinolin-6-yl)methyl]piperidin-1-yl}carbonyl)-2-phenylquinoline (3 entities in total)
• 機能のキーワード: transferase, acetyl-coa carboxylase, carboxyltransferase, inhibitor, ligase
• 由来する生物種: Saccharomyces cerevisiae (yeast)
• 細胞内の位置: Cytoplasm: Q00955
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 263128.71

構造登録者

Zhang, H.,Tong, L. (登録日: 2009-04-10, 公開日: 2010-04-21, 最終更新日: 2024-02-21)

• 主引用文献: Corbett, J.W.,Freeman-Cook, K.D.,Elliott, R.,Vajdos, F.,Rajamohan, F.,Kohls, D.,Marr, E.,Zhang, H.,Tong, L.,Tu, M.,Murdande, S.,Doran, S.D.,Houser, J.A.,Song, W.,Jones, C.J.,Coffey, S.B.,Buzon, L.,Minich, M.L.,Dirico, K.J.,Tapley, S.,McPherson, R.K.,Sugarman, E.,Harwood, H.J.,Esler, W.; Discovery of small molecule isozyme non-specific inhibitors of mammalian acetyl-CoA carboxylase 1 and 2.; Bioorg.Med.Chem.Lett., 20:2383-2388, 2010; PubMed: 20219367; DOI: 10.1016/j.bmcl.2009.04.091

実験手法

X-RAY DIFFRACTION (2.5 Å)