3GZJ

Crystal Structure of Polyneuridine Aldehyde Esterase Complexed with 16-epi-Vellosimine

3GZJ の概要

• エントリーDOI: 10.2210/pdb3gzj/pdb
• 分子名称: Polyneuridine-aldehyde esterase, 16-epi-Vellosimine (3 entities in total)
• 機能のキーワード: hydrolase superfamily, alkaloid metabolism, hydrolase, serine esterase
• 由来する生物種: Rauvolfia serpentina (devilpepper)
• タンパク質・核酸の鎖数: 5
• 化学式量合計: 146227.65

構造登録者

Yang, L.,Hill, M.,Wang, M.,Panjikar, S.,Stoeckigt, J. (登録日: 2009-04-07, 公開日: 2009-08-18, 最終更新日: 2023-11-01)

主引用文献

Yang, L.,Hill, M.,Wang, M.,Panjikar, S.,Stockigt, J.
Structural basis and enzymatic mechanism of the biosynthesis of C9- from C10-monoterpenoid indole alkaloids
Angew.Chem.Int.Ed.Engl., 48:5211-5213, 2009

PubMed Abstract: Cutting carbons: The three-dimensional structure of polyneuridine aldehyde esterase (PNAE) gives insight into the enzymatic mechanism of the biosynthesis of C(9)- from C(10)-monoterpenoid indole alkaloids (see scheme). PNAE is a very substrate-specific serine esterase. It harbors the catalytic triad S87-D216-H244, and is a new member of the alpha/beta-fold hydrolase superfamily. Its novel function leads to the diversification of alkaloid structures.

PubMed: 19496101
DOI: 10.1002/anie.200900150

実験手法

X-RAY DIFFRACTION (2.19 Å)