3GYU

Nuclear receptor DAF-12 from parasitic nematode Strongyloides stercoralis in complex with its physiological ligand dafachronic acid delta 7

3GYU の概要

• エントリーDOI: 10.2210/pdb3gyu/pdb
• 関連するPDBエントリー: 3GYT
• 分子名称: Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily, SRC1, (5beta,14beta,17alpha,25R)-3-oxocholest-7-en-26-oic acid, ... (4 entities in total)
• 機能のキーワード: nuclear receptor, ligand binding domain, dafachronic acid, src1, nematode, strongyloides stercoralis, dna-binding, metal-binding, nucleus, receptor, transcription, transcription regulation, zinc, zinc-finger
• 由来する生物種: Strongyloides stercoralis
• 細胞内の位置: Nucleus : Q9XZJ5
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 30088.36

構造登録者

Zhou, X.E.,Wang, Z.,Suino-Powell, K.,Motola, D.L.,Conneely, A.,Ogata, C.,Sharma, K.K.,Auchus, R.J.,Kliewer, S.A.,Xu, H.E.,Mangelsdorf, D.J. (登録日: 2009-04-05, 公開日: 2009-07-07, 最終更新日: 2024-04-03)

• 主引用文献: Wang, Z.,Zhou, X.E.,Motola, D.L.,Gao, X.,Suino-Powell, K.,Conneely, A.,Ogata, C.,Sharma, K.K.,Auchus, R.J.,Lok, J.B.,Hawdon, J.M.,Kliewer, S.A.,Xu, H.E.,Mangelsdorf, D.J.; Identification of the nuclear receptor DAF-12 as a therapeutic target in parasitic nematodes.; Proc.Natl.Acad.Sci.USA, 106:9138-9143, 2009; PubMed: 19497877; DOI: 10.1073/pnas.0904064106

実験手法

X-RAY DIFFRACTION (2.4 Å)