3GW5
Crystal structure of human renin complexed with a novel inhibitor
Summary for 3GW5
Entry DOI | 10.2210/pdb3gw5/pdb |
Descriptor | Renin, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, (3R)-3-[(1S)-1-(3-chlorophenyl)-1-hydroxy-5-methoxypentyl]-N-{(1S)-2-cyclohexyl-1-[(methylamino)methyl]ethyl}piperidine-1-carboxamide, ... (7 entities in total) |
Functional Keywords | renin, aspartate protease, hypertension, renin expression, renin inhibitor, aspartyl protease, cleavage on pair of basic residues, disease mutation, disulfide bond, glycoprotein, hydrolase, membrane, protease, secreted, zymogen, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Secreted: P00797 |
Total number of polymer chains | 2 |
Total formula weight | 76036.99 |
Authors | Wu, Z.,McKeever, B.M. (deposition date: 2009-03-31, release date: 2009-06-23, Last modification date: 2023-09-06) |
Primary citation | Tice, C.M.,Xu, Z.,Yuan, J.,Simpson, R.D.,Cacatian, S.T.,Flaherty, P.T.,Zhao, W.,Guo, J.,Ishchenko, A.,Singh, S.B.,Wu, Z.,Scott, B.B.,Bukhtiyarov, Y.,Berbaum, J.,Mason, J.,Panemangalore, R.,Cappiello, M.G.,Muller, D.,Harrison, R.K.,McGeehan, G.M.,Dillard, L.W.,Baldwin, J.J.,Claremon, D.A. Design and optimization of renin inhibitors: Orally bioavailable alkyl amines. Bioorg.Med.Chem.Lett., 19:3541-3545, 2009 Cited by PubMed: 19457666DOI: 10.1016/j.bmcl.2009.04.140 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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