3GRW

FGFR3 in complex with a Fab

3GRW の概要

• エントリーDOI: 10.2210/pdb3grw/pdb
• 分子名称: Fibroblast growth factor receptor 3, Fab light chain, Fab heavy chain, ... (6 entities in total)
• 機能のキーワード: fgfr3, fab, protein-protein complex, receptor tyrosine kinase, atp-binding, immunoglobulin domain, kinase, membrane, nucleotide-binding, receptor, transferase, transmembrane, tyrosine-protein kinase, transferase-immune system complex, transferase/immune system
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 75436.03

構造登録者

Wiesmann, C. (登録日: 2009-03-26, 公開日: 2009-05-05, 最終更新日: 2020-07-29)

• 主引用文献: Qing, J.,Du, X.,Chen, Y.,Chan, P.,Li, H.,Wu, P.,Marsters, S.,Stawicki, S.,Tien, J.,Totpal, K.,Ross, S.,Stinson, S.,Dornan, D.,French, D.,Wang, Q.R.,Stephan, J.P.,Wu, Y.,Wiesmann, C.,Ashkenazi, A.; Antibody-based targeting of FGFR3 in bladder carcinoma and t(4;14)-positive multiple myeloma in mice.; J.Clin.Invest., 119:1216-1229, 2009; PubMed: 19381019; DOI: 10.1172/JCI38017

実験手法

X-RAY DIFFRACTION (2.1 Å)