3GPH

Human cytochrome P450 2E1 in complex with omega-imidazolyl-decanoic acid

Summary for 3GPH

• Entry DOI: 10.2210/pdb3gph/pdb
• Related: 3E4E 3E6I
• Descriptor: Cytochrome P450 2E1, PROTOPORPHYRIN IX CONTAINING FE, 10-(1H-imidazol-1-yl)decanoic acid, ... (4 entities in total)
• Functional Keywords: cyp2e1, p450 2e1, monooxygenase, acetaminophen, oxidoreductase, heme, fatty acid hydroxylase, metal-binding
• Biological source: Homo sapiens (Human)
• Cellular location: Endoplasmic reticulum membrane; Peripheral membrane protein: P05181
• Total number of polymer chains: 2
• Total formula weight: 111826.60

Authors

Porubsky, P.R.,Battaile, K.P.,Scott, E.E. (deposition date: 2009-03-23, release date: 2010-05-12, Last modification date: 2023-09-06)

• Primary citation: Porubsky, P.R.,Battaile, K.P.,Scott, E.E.; Human cytochrome P450 2E1 structures with fatty acid analogs reveal a previously unobserved binding mode.; J.Biol.Chem., 285:22282-22290, 2010; PubMed: 20463018; DOI: 10.1074/jbc.M110.109017

Experimental method

X-RAY DIFFRACTION (2.7 Å)