3GOY

Crystal structure of human poly(adp-ribose) polymerase 14, catalytic fragment in complex with an inhibitor 3-aminobenzamide

3GOY の概要

• エントリーDOI: 10.2210/pdb3goy/pdb
• 分子名称: Poly [ADP-ribose] polymerase 14, 3-aminobenzamide (2 entities in total)
• 機能のキーワード: parp, poly(adp-ribose) polymerase, bal-2, sgc, structural genomics consortium, nad, transferase, glycosyltransferase, nucleus, transcription, transcription regulation, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Nucleus: Q460N5
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 89018.96

構造登録者

Karlberg, T.,Moche, M.,Lehtio, L.,Arrowsmith, C.H.,Berglund, H.,Bountra, C.,Collins, R.,Edwards, A.M.,Flodin, S.,Flores, A.,Graslund, S.,Hammarstrom, M.,Johansson, A.,Johansson, I.,Kotenyova, T.,Nordlund, P.,Nyman, T.,Persson, C.,Sagemark, J.,Schutz, P.,Siponen, M.I.,Thorsell, A.G.,Tresaugues, L.,Van Den Berg, S.,Weigelt, J.,Welin, M.,Wisniewska, M.,Schuler, H.,Structural Genomics Consortium (SGC) (登録日: 2009-03-20, 公開日: 2009-04-14, 最終更新日: 2023-09-06)

• 主引用文献: Wahlberg, E.,Karlberg, T.,Kouznetsova, E.,Markova, N.,Macchiarulo, A.,Thorsell, A.G.,Pol, E.,Frostell, A.,Ekblad, T.,Oncu, D.,Kull, B.,Robertson, G.M.,Pellicciari, R.,Schuler, H.,Weigelt, J.; Family-wide chemical profiling and structural analysis of PARP and tankyrase inhibitors.; Nat.Biotechnol., 30:283-288, 2012; PubMed: 22343925; DOI: 10.1038/nbt.2121

実験手法

X-RAY DIFFRACTION (2.8 Å)