3GOR

Crystal structure of putative metal-dependent hydrolase APC36150

「3E4X」から置き換えられました

3GOR の概要

• エントリーDOI: 10.2210/pdb3gor/pdb
• 分子名称: Putative metal-dependent hydrolase, NICKEL (II) ION (3 entities in total)
• 機能のキーワード: structural genomics, dinb superfamily, psi-2, protein structure initiative, integrated center for structure and function innovation, isfi, unknown function
• 由来する生物種: Geobacillus stearothermophilus
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 74754.49

構造登録者

Cooper, D.R.,Grelewska, K.,Derewenda, Z.S.,Integrated Center for Structure and Function Innovation (ISFI) (登録日: 2009-03-19, 公開日: 2009-05-19, 最終更新日: 2024-10-30)

主引用文献

Cooper, D.R.,Grelewska, K.,Kim, C.Y.,Joachimiak, A.,Derewenda, Z.S.
The structure of DinB from Geobacillus stearothermophilus: a representative of a unique four-helix-bundle superfamily.
Acta Crystallogr.,Sect.F, 66:219-224, 2010

PubMed Abstract: The crystal structure of the dinB gene product from Geobacillus stearothermophilus (GsDinB) is reported at 2.5 A resolution. The dinB gene is one of the DNA-damage-induced genes and the corresponding protein, DinB, is the founding member of a Pfam family with no known function. The protein contains a four-helix up-down-down-up bundle that has previously been described in the literature in three disparate proteins: the enzyme MDMPI (mycothiol-dependent maleylpyruvate isomerase), YfiT and TTHA0303, a member of a small DUF (domain of unknown function). However, a search of the DALI structural database revealed similarities to a further 11 new unpublished structures contributed by structural genomics centers. The sequences of these proteins are quite divergent and represent several Pfam families, yet their structures are quite similar and most (but not all) seem to have the ability to coordinate a metal ion using a conserved histidine-triad motif. The structural similarities of these diverse proteins suggest that a new Pfam clan encompassing the families that share this fold should be created. The proteins that share this fold exhibit four different quaternary structures: monomeric and three different dimeric forms.

PubMed: 20208147
DOI: 10.1107/S1744309109053913

実験手法

X-RAY DIFFRACTION (2.511 Å)