3GN8
X-ray Crystal Structure of AncGR2 in Complex with Dexamethasone
Summary for 3GN8
Entry DOI | 10.2210/pdb3gn8/pdb |
Descriptor | Glucocorticoid receptor 2, Nuclear receptor coactivator 2, DEXAMETHASONE, ... (4 entities in total) |
Functional Keywords | nuclear receptor, gr2, evolution, glucocorticoid receptor, dexamethasone, cortisol, activator, nucleus, phosphoprotein, polymorphism, transcription, transcription regulation, hormone-hormone activator complex, hormone/hormone activator |
Biological source | Homo sapiens (human) More |
Cellular location | Nucleus: 3GN8 |
Total number of polymer chains | 4 |
Total formula weight | 63087.49 |
Authors | Ortlund, E.A. (deposition date: 2009-03-16, release date: 2009-09-22, Last modification date: 2023-09-06) |
Primary citation | Bridgham, J.T.,Ortlund, E.A.,Thornton, J.W. An epistatic ratchet constrains the direction of glucocorticoid receptor evolution Nature, 461:515-519, 2009 Cited by PubMed: 19779450DOI: 10.1038/nature08249 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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