3GN8

X-ray Crystal Structure of AncGR2 in Complex with Dexamethasone

3GN8 の概要

• エントリーDOI: 10.2210/pdb3gn8/pdb
• 分子名称: Glucocorticoid receptor 2, Nuclear receptor coactivator 2, DEXAMETHASONE, ... (4 entities in total)
• 機能のキーワード: nuclear receptor, gr2, evolution, glucocorticoid receptor, dexamethasone, cortisol, activator, nucleus, phosphoprotein, polymorphism, transcription, transcription regulation, hormone-hormone activator complex, hormone/hormone activator
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Nucleus: 3GN8
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 63087.49

構造登録者

Ortlund, E.A. (登録日: 2009-03-16, 公開日: 2009-09-22, 最終更新日: 2023-09-06)

• 主引用文献: Bridgham, J.T.,Ortlund, E.A.,Thornton, J.W.; An epistatic ratchet constrains the direction of glucocorticoid receptor evolution; Nature, 461:515-519, 2009; PubMed: 19779450; DOI: 10.1038/nature08249

実験手法

X-RAY DIFFRACTION (2.5 Å)