3GI3
Crystal structure of a N-Phenyl-N'-Naphthylurea analog in complex with p38 MAP kinase
Summary for 3GI3
Entry DOI | 10.2210/pdb3gi3/pdb |
Descriptor | Mitogen-activated protein kinase 14, N-{5-tert-butyl-2-methoxy-3-[({4-[6-(morpholin-4-ylmethyl)pyridin-3-yl]naphthalen-1-yl}carbamoyl)amino]phenyl}methanesulfonamide (3 entities in total) |
Functional Keywords | two lobe kinase structure, n-lobe beta-sheet, c-lobe alpha-helix, alternative splicing, atp-binding, cytoplasm, kinase, nucleotide-binding, nucleus, phosphoprotein, polymorphism, serine/threonine-protein kinase, transferase |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm (By similarity): Q16539 |
Total number of polymer chains | 1 |
Total formula weight | 42092.07 |
Authors | Qian, K.C. (deposition date: 2009-03-05, release date: 2009-10-20, Last modification date: 2024-02-21) |
Primary citation | Cirillo, P.F.,Hickey, E.R.,Moss, N.,Breitfelder, S.,Betageri, R.,Fadra, T.,Gaenzler, F.,Gilmore, T.,Goldberg, D.R.,Kamhi, V.,Kirrane, T.,Kroe, R.R.,Madwed, J.,Moriak, M.,Netherton, M.,Pargellis, C.A.,Patel, U.R.,Qian, K.C.,Sharma, R.,Sun, S.,Swinamer, A.,Torcellini, C.,Takahashi, H.,Tsang, M.,Xiong, Z. Discovery and characterization of the N-phenyl-N'-naphthylurea class of p38 kinase inhibitors. Bioorg.Med.Chem.Lett., 19:2386-2391, 2009 Cited by PubMed: 19356929DOI: 10.1016/j.bmcl.2009.03.104 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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