3GI3

Crystal structure of a N-Phenyl-N'-Naphthylurea analog in complex with p38 MAP kinase

3GI3 の概要

• エントリーDOI: 10.2210/pdb3gi3/pdb
• 分子名称: Mitogen-activated protein kinase 14, N-{5-tert-butyl-2-methoxy-3-[({4-[6-(morpholin-4-ylmethyl)pyridin-3-yl]naphthalen-1-yl}carbamoyl)amino]phenyl}methanesulfonamide (3 entities in total)
• 機能のキーワード: two lobe kinase structure, n-lobe beta-sheet, c-lobe alpha-helix, alternative splicing, atp-binding, cytoplasm, kinase, nucleotide-binding, nucleus, phosphoprotein, polymorphism, serine/threonine-protein kinase, transferase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm (By similarity): Q16539
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 42092.07

構造登録者

Qian, K.C. (登録日: 2009-03-05, 公開日: 2009-10-20, 最終更新日: 2024-02-21)

• 主引用文献: Cirillo, P.F.,Hickey, E.R.,Moss, N.,Breitfelder, S.,Betageri, R.,Fadra, T.,Gaenzler, F.,Gilmore, T.,Goldberg, D.R.,Kamhi, V.,Kirrane, T.,Kroe, R.R.,Madwed, J.,Moriak, M.,Netherton, M.,Pargellis, C.A.,Patel, U.R.,Qian, K.C.,Sharma, R.,Sun, S.,Swinamer, A.,Torcellini, C.,Takahashi, H.,Tsang, M.,Xiong, Z.; Discovery and characterization of the N-phenyl-N'-naphthylurea class of p38 kinase inhibitors.; Bioorg.Med.Chem.Lett., 19:2386-2391, 2009; PubMed: 19356929; DOI: 10.1016/j.bmcl.2009.03.104

実験手法

X-RAY DIFFRACTION (2.4 Å)