3GI2
Human dihydrofolate reductase Q35K mutant inhibitor complex
3GI2 の概要
エントリーDOI | 10.2210/pdb3gi2/pdb |
分子名称 | Dihydrofolate reductase, N-({4-[(2-amino-6-methyl-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-5-yl)sulfanyl]phenyl}carbonyl)-L-glutamic acid, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (4 entities in total) |
機能のキーワード | dihydrofolate reductase, folate enzyme, active site mutants, nadp, one-carbon metabolism, oxidoreductase |
由来する生物種 | Homo sapiens (human) |
タンパク質・核酸の鎖数 | 1 |
化学式量合計 | 22689.69 |
構造登録者 | |
主引用文献 | Gangjee, A.,Li, W.,Kisliuk, R.L.,Cody, V.,Pace, J.,Piraino, J.,Makin, J. Design, synthesis, and X-ray crystal structure of classical and nonclassical 2-amino-4-oxo-5-substituted-6-ethylthieno[2,3-d]pyrimidines as dual thymidylate synthase and dihydrofolate reductase inhibitors and as potential antitumor agents. J.Med.Chem., 52:4892-4902, 2009 Cited by PubMed: 19719239DOI: 10.1021/jm900490a 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (1.53 Å) |
構造検証レポート
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