3GHH

Structural insights into the catalytic mechanism of CD38: Evidence for a conformationally flexible covalent enzyme-substrate complex.

3GHH の概要

• エントリーDOI: 10.2210/pdb3ghh/pdb
• 関連するPDBエントリー: 1YH3 3GC6 3GH3
• 分子名称: Ecto-NAD+ glycohydrolase (CD38 molecule), 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, SULFATE ION, ... (5 entities in total)
• 機能のキーワード: cd38, cyclic adp ribose, ecto-adp-ribosyl cyclase, 2-glycosidase, glycosidase, hydrolase
• 由来する生物種: Bos taurus (bovine,cow,domestic cattle,domestic cow)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 58594.66

構造登録者

Egea, P.F.,Muller-Steffner, H.,Stroud, R.M.,Oppenheimer, N.J.,Kellenberger, E.,Schuber, F. (登録日: 2009-03-03, 公開日: 2010-03-16, 最終更新日: 2023-09-06)

• 主引用文献: Egea, P.F.,Muller-Steffner, H.,Kuhn, I.,Cakir-Kiefer, C.,Oppenheimer, N.J.,Stroud, R.M.,Kellenberger, E.,Schuber, F.; Insights into the mechanism of bovine CD38/NAD+glycohydrolase from the X-ray structures of its Michaelis complex and covalently-trapped intermediates.; Plos One, 7:e34918-e34918, 2012; PubMed: 22529956; DOI: 10.1371/journal.pone.0034918

実験手法

X-RAY DIFFRACTION (1.94 Å)