3GH3
Structural insights into the catalytic mechanism of CD38: Evidence for a conformationally flexible covalent enzyme-substrate complex.
Summary for 3GH3
Entry DOI | 10.2210/pdb3gh3/pdb |
Related | 1YH3 3GC6 |
Descriptor | Ecto-NAD+ glycohydrolase (CD38 molecule), 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, SULFATE ION, ... (5 entities in total) |
Functional Keywords | cd38, cyclic adp ribose, ecto-adp-ribosyl cyclase, 2 glycosidase, hydrolase, glycosidase |
Biological source | Bos taurus (bovine,cow,domestic cattle,domestic cow) |
Total number of polymer chains | 2 |
Total formula weight | 57780.01 |
Authors | Egea, P.F.,Muller-Steffner, H.,Stroud, R.M.,Kellenberger, E.,Oppenheimer, N.,Schuber, F. (deposition date: 2009-03-02, release date: 2010-03-16, Last modification date: 2023-09-06) |
Primary citation | Egea, P.F.,Muller-Steffner, H.,Kuhn, I.,Cakir-Kiefer, C.,Oppenheimer, N.J.,Stroud, R.M.,Kellenberger, E.,Schuber, F. Insights into the mechanism of bovine CD38/NAD+glycohydrolase from the X-ray structures of its Michaelis complex and covalently-trapped intermediates. Plos One, 7:e34918-e34918, 2012 Cited by PubMed: 22529956DOI: 10.1371/journal.pone.0034918 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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