3GFW

Crystal Structure of Human Dual Specificity Protein Kinase (TTK) in complex with a pyrolo-pyridin ligand

3GFW の概要

• エントリーDOI: 10.2210/pdb3gfw/pdb
• 分子名称: Dual specificity protein kinase TTK, 1-(4-(4-(2-(isopropylsulfonyl)phenylamino)-1H-pyrrolo[2,3-b]pyridin-6-ylamino)-3-methoxyphenyl)piperidin-4-ol, 2-(2-(2-(2-(2-(2-ETHOXYETHOXY)ETHOXY)ETHOXY)ETHOXY)ETHOXY)ETHANOL, ... (4 entities in total)
• 機能のキーワード: ttk, hmps1, pyt, esk, kinase, dual specificity, phosphotyrosine picked threonine kinase, sgc, structural genomics consortium, atp-binding, nucleotide-binding, phosphoprotein, serine/threonine-protein kinase, transferase, tyrosine-protein kinase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 37271.68

構造登録者

Filippakopoulos, P.,Soundararajan, M.,Choi, H.,Keates, T.,Elkins, J.M.,King, O.,Fedorov, O.,Picaud, S.S.,Pike, A.C.W.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.,Weigelt, J.,Bountra, C.,Grey, N.,Knapp, S.,Structural Genomics Consortium (SGC) (登録日: 2009-02-27, 公開日: 2009-03-17, 最終更新日: 2023-09-06)

• 主引用文献: Kwiatkowski, N.,Jelluma, N.,Filippakopoulos, P.,Soundararajan, M.,Manak, M.S.,Kwon, M.,Choi, H.G.,Sim, T.,Deveraux, Q.L.,Rottmann, S.,Pellman, D.,Shah, J.V.,Kops, G.J.,Knapp, S.,Gray, N.S.; Small-molecule kinase inhibitors provide insight into Mps1 cell cycle function.; Nat.Chem.Biol., 6:359-368, 2010; PubMed: 20383151; DOI: 10.1038/nchembio.345

実験手法

X-RAY DIFFRACTION (2.74 Å)