3GCS

Human P38 MAP kinase in complex with Sorafenib

3GCS の概要

• エントリーDOI: 10.2210/pdb3gcs/pdb
• 関連するPDBエントリー: 3GCQ 3GCU
• 分子名称: Mitogen-activated protein kinase 14, 4-{4-[({[4-CHLORO-3-(TRIFLUOROMETHYL)PHENYL]AMINO}CARBONYL)AMINO]PHENOXY}-N-METHYLPYRIDINE-2-CARBOXAMIDE, octyl beta-D-glucopyranoside, ... (4 entities in total)
• 機能のキーワード: dfg-out, type ii, bay439006, atp-binding, kinase, nucleotide-binding, nucleus, phosphoprotein, serine/threonine-protein kinase, transferase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 41992.17

構造登録者

Gruetter, C.,Simard, J.R.,Rauh, D. (登録日: 2009-02-22, 公開日: 2009-06-09, 最終更新日: 2023-09-06)

• 主引用文献: Simard, J.R.,Getlik, M.,Grutter, C.,Pawar, V.,Wulfert, S.,Rabiller, M.,Rauh, D.; Development of a fluorescent-tagged kinase assay system for the detection and characterization of allosteric kinase inhibitors.; J.Am.Chem.Soc., 131:13286-13296, 2009; PubMed: 19572644; DOI: 10.1021/ja902010p

実験手法

X-RAY DIFFRACTION (2.1 Å)