3GCD

Structure of the V. cholerae RTX cysteine protease domain in complex with an aza-Leucine peptide inhibitor

3GCD の概要

• エントリーDOI: 10.2210/pdb3gcd/pdb
• 関連するBIRD辞書のPRD_ID: PRD_000439
• 分子名称: RTX toxin RtxA, ethyl (5S,8S,14S)-14-hydroxy-5,8,11-tris(2-methylpropyl)-3,6,9,12-tetraoxo-1-phenyl-2-oxa-4,7,10,11-tetraazapentadecan-15-oate, INOSITOL HEXAKISPHOSPHATE, ... (5 entities in total)
• 機能のキーワード: v. cholerae, repeats-in-toxin, martx, cysteine protease, inositol hexakisphosphate, aza-peptide, aza-leu, toxin-inhibitor complex, toxin/inhibitor
• 由来する生物種: Vibrio cholerae
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 95942.68

構造登録者

Lupardus, P.J.,Garcia, K.C.,Shen, A.,Bogyo, M. (登録日: 2009-02-21, 公開日: 2009-05-26, 最終更新日: 2023-09-06)

• 主引用文献: Shen, A.,Lupardus, P.J.,Albrow, V.E.,Guzzetta, A.,Powers, J.C.,Garcia, K.C.,Bogyo, M.; Mechanistic and structural insights into the proteolytic activation of Vibrio cholerae MARTX toxin.; Nat.Chem.Biol., 5:469-478, 2009; PubMed: 19465933; DOI: 10.1038/nchembio.178

実験手法

X-RAY DIFFRACTION (2.35 Å)