3GC6
Structural insights into the catalytic mechanism of CD38: Evidence for a conformationally flexible covalent enzyme-substrate complex.
3GC6 の概要
エントリーDOI | 10.2210/pdb3gc6/pdb |
分子名称 | Ecto-NAD+ glycohydrolase (CD38 molecule), 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, SULFATE ION, ... (4 entities in total) |
機能のキーワード | cd38, cyclic adp ribose, ecto-adp-ribosyl cyclase, glycosidase, hydrolase |
由来する生物種 | Bos taurus (bovine,cow,domestic cattle,domestic cow) |
タンパク質・核酸の鎖数 | 2 |
化学式量合計 | 57929.24 |
構造登録者 | Egea, P.F.,Muller-Steffner, H.,Stroud, R.M.,Oppenheimer, N.,Kellenberger, E.,Schuber, F. (登録日: 2009-02-21, 公開日: 2010-03-02, 最終更新日: 2023-09-06) |
主引用文献 | Egea, P.F.,Muller-Steffner, H.,Kuhn, I.,Cakir-Kiefer, C.,Oppenheimer, N.J.,Stroud, R.M.,Kellenberger, E.,Schuber, F. Insights into the mechanism of bovine CD38/NAD+glycohydrolase from the X-ray structures of its Michaelis complex and covalently-trapped intermediates. Plos One, 7:e34918-e34918, 2012 Cited by PubMed: 22529956DOI: 10.1371/journal.pone.0034918 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (1.51 Å) |
構造検証レポート
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