3GBK
Crystal Structure of Human PPAR-gamma Ligand Binding Domain Complexed with a Potent and Selective Agonist
3GBK の概要
エントリーDOI | 10.2210/pdb3gbk/pdb |
分子名称 | Peroxisome proliferator-activated receptor gamma, 2-[(1-{3-[4-(biphenyl-4-ylcarbonyl)-2-propylphenoxy]propyl}-1,2,3,4-tetrahydroquinolin-5-yl)oxy]-2-methylpropanoic acid (3 entities in total) |
機能のキーワード | ppar aganists, x-ray co-crystal analysis, structure-based drug design, selective, type ii diabetes, activator, alternative splicing, diabetes mellitus, disease mutation, dna-binding, metal-binding, nucleus, obesity, phosphoprotein, polymorphism, receptor, transcription, transcription regulation, zinc, zinc-finger, ligand binding protein |
由来する生物種 | Homo sapiens (Human) |
細胞内の位置 | Nucleus: P37231 |
タンパク質・核酸の鎖数 | 2 |
化学式量合計 | 62585.78 |
構造登録者 | |
主引用文献 | Lin, C.-H.,Peng, Y.-H.,Coumar, M.S.,Chittimalla, S.K.,Liao, C.-C.,Lyn, P.-C.,Huang, C.-C.,Lien, T.-W.,Lin, W.-H.,Hsu, J.T.-A.,Cheng, J.-H.,Chen, X.,Wu, J.-S.,Chao, Y.-S.,Lee, H.-J.,Juo, C.-G.,Wu, S.-Y.,Hsieh, H.-P. Design and structural analysis of novel pharmacophores for potent and selective peroxisome proliferator-activated receptor gamma agonists J.Med.Chem., 52:2618-2622, 2009 Cited by PubMed: 19301897DOI: 10.1021/jm801594x 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (2.3 Å) |
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