3GA1

Crystal Structure of the Human Nac1 POZ Domain

3GA1 の概要

• エントリーDOI: 10.2210/pdb3ga1/pdb
• 分子名称: Nucleus accumbens-associated protein 1, NITRATE ION (3 entities in total)
• 機能のキーワード: btb/poz domain, nucleus, phosphoprotein, repressor, transcription, transcription regulation
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Nucleus: Q96RE7
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 28788.50

構造登録者

Stead, M.A.,Carr, S.B.,Wright, S.C. (登録日: 2009-02-16, 公開日: 2009-05-19, 最終更新日: 2023-11-01)

主引用文献

Stead, M.A.,Carr, S.B.,Wright, S.C.
Structure of the human Nac1 POZ domain
Acta Crystallogr.,Sect.F, 65:445-449, 2009

PubMed Abstract: Nac1 is a POZ-domain transcription factor that is involved in the self-renewal of embryonic stem cells. It is overexpressed in ovarian serous carcinoma and targeting the interactions of its POZ domain is a potential therapeutic strategy. Nac1 lacks a zinc-finger DNA-binding domain and thereby differs from most other POZ-domain transcription factors. Here, the crystal structure of the Nac1 POZ domain at 2.1 A resolution is reported. The Nac1 POZ domain crystallized as a dimer in which the interaction interfaces between subunits resemble those found in the POZ-zinc finger transcription factors. The organization of the Nac1 POZ-domain core resembles reported POZ-domain structures, whereas the C-terminus differs markedly. The C-terminal alpha-helix of the Nac1 POZ domain is shorter than that observed in most other POZ-domain transcription factors; variation in the organization of this region may be a general feature of POZ-domain structures.

PubMed: 19407373
DOI: 10.1107/S1744309109012214

実験手法

X-RAY DIFFRACTION (2.1 Å)