3G90

JNK-3 bound to (Z)-5-fluoro-1-((6-fluoro-4H-benzo[d][1,3]dioxin-8-yl)methyl)-3-(hydroxyimino)indolin-2-one

3G90 の概要

• エントリーDOI: 10.2210/pdb3g90/pdb
• 関連するPDBエントリー: 3G9L 3G9N
• 分子名称: Mitogen-activated protein kinase 10, (3E)-5-fluoro-1-[(6-fluoro-4H-1,3-benzodioxin-8-yl)methyl]-1H-indole-2,3-dione 3-oxime (3 entities in total)
• 機能のキーワード: kinase, inhibitor, phosphorylation, atp-binding, epilepsy, nucleotide-binding, phosphoprotein, serine/threonine-protein kinase, transferase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm: P53779
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 42463.01

構造登録者

Xie, X.,Jacobs, M.D. (登録日: 2009-02-12, 公開日: 2009-02-24, 最終更新日: 2024-02-21)

• 主引用文献: Cao, J.,Gao, H.,Bemis, G.,Salituro, F.,Ledeboer, M.,Harrington, E.,Wilke, S.,Taslimi, P.,Pazhanisamy, S.,Xie, X.,Jacobs, M.,Green, J.; Structure-based design and parallel synthesis of N-benzyl isatin oximes as JNK3 MAP kinase inhibitors.; Bioorg.Med.Chem.Lett., 19:2891-2895, 2009; PubMed: 19361991; DOI: 10.1016/j.bmcl.2009.03.043

実験手法

X-RAY DIFFRACTION (2.4 Å)