3G80

Nodamura virus protein b2, RNA-binding domain

3G80 の概要

• エントリーDOI: 10.2210/pdb3g80/pdb
• 分子名称: Protein B2 (2 entities in total)
• 機能のキーワード: rna-binding, viral protein, suppressor of rnai, rna interference
• 由来する生物種: Nodamura virus (NoV)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 22273.53

構造登録者

Korber, S.,Shaik Syed Ali, P.,Chen, J.C. (登録日: 2009-02-11, 公開日: 2010-01-05, 最終更新日: 2023-09-06)

主引用文献

Korber, S.,Shaik Syed Ali, P.,Chen, J.C.
Structure of the RNA-Binding Domain of Nodamura Virus Protein B2, a Suppressor of RNA Interference.
Biochemistry, 48:2307-2309, 2009

PubMed Abstract: Protein B2 from Nodamura virus (NMV B2), a member of the Nodavirus family, acts as a suppressor of RNA interference (RNAi). The N-terminal domain of NMV B2, consisting of residues 1-79, recognizes double-stranded RNA (dsRNA). The 2.5 A crystal structure of the RNA-binding domain of NMV B2 shows a dimeric, helical bundle structure. The structure shows a conserved set of RNA-binding residues compared with flock house virus B2, despite limited sequence identity. The crystal packing places the RNA-binding residues along one face of symmetry-related molecules, suggesting a potential platform for recognition of dsRNA.

PubMed: 19249868
DOI: 10.1021/bi900126s

実験手法

X-RAY DIFFRACTION (2.5 Å)