3G75
Crystal structure of Staphylococcus aureus Gyrase B co-complexed with 4-METHYL-5-[3-(METHYLSULFANYL)-1H-PYRAZOL-5-YL]-2-THIOPHEN-2-YL-1,3-THIAZOLE inhibitor
Summary for 3G75
Entry DOI | 10.2210/pdb3g75/pdb |
Related | 3G7B 3G7E |
Descriptor | DNA gyrase subunit B, 4-methyl-5-[3-(methylsulfanyl)-1H-pyrazol-5-yl]-2-thiophen-2-yl-1,3-thiazole (3 entities in total) |
Functional Keywords | antibiotic resistance, isomerase, isomerase-isomerase inhibitor complex, isomerase/isomerase inhibitor |
Biological source | Staphylococcus aureus |
Cellular location | Cytoplasm (Potential): P0A0K8 |
Total number of polymer chains | 2 |
Total formula weight | 42842.04 |
Authors | Wei, Y.,Charifson, P. (deposition date: 2009-02-09, release date: 2010-02-09, Last modification date: 2024-02-21) |
Primary citation | Ronkin, S.M.,Badia, M.,Bellon, S.,Grillot, A.L.,Gross, C.H.,Grossman, T.H.,Mani, N.,Parsons, J.D.,Stamos, D.,Trudeau, M.,Wei, Y.,Charifson, P.S. Discovery of pyrazolthiazoles as novel and potent inhibitors of bacterial gyrase. Bioorg.Med.Chem.Lett., 20:2828-2831, 2010 Cited by PubMed: 20356737DOI: 10.1016/j.bmcl.2010.03.052 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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