3G0E

KIT kinase domain in complex with sunitinib

3G0E の概要

• エントリーDOI: 10.2210/pdb3g0e/pdb
• 関連するPDBエントリー: 3G0F
• 分子名称: Mast/stem cell growth factor receptor, N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carbo xamide (3 entities in total)
• 機能のキーワード: kit kinase domain, sutent binding, drug resistance, atp-binding, disease mutation, glycoprotein, immunoglobulin domain, kinase, membrane, nucleotide-binding, phosphoprotein, polymorphism, proto-oncogene, receptor, transmembrane, tyrosine-protein kinase, transferase
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Cell membrane; Single-pass type I membrane protein. Isoform 3: Cytoplasm: P10721
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 38615.65

構造登録者

Gajiwala, K.S.,Wu, J.C.,Lunney, E.A.,Gemetri, G.D. (登録日: 2009-01-27, 公開日: 2009-02-24, 最終更新日: 2023-09-06)

• 主引用文献: Gajiwala, K.S.,Wu, J.C.,Christensen, J.,Deshmukh, G.D.,Diehl, W.,DiNitto, J.P.,English, J.M.,Greig, M.J.,He, Y.A.,Jacques, S.L.,Lunney, E.A.,McTigue, M.,Molina, D.,Quenzer, T.,Wells, P.A.,Yu, X.,Zhang, Y.,Zou, A.,Emmett, M.R.,Marshall, A.G.,Zhang, H.M.,Demetri, G.D.; KIT kinase mutants show unique mechanisms of drug resistance to imatinib and sunitinib in gastrointestinal stromal tumor patients.; Proc.Natl.Acad.Sci.USA, 106:1542-1547, 2009; PubMed: 19164557; DOI: 10.1073/pnas.0812413106

実験手法

X-RAY DIFFRACTION (1.6 Å)