3FV7

OXA-24 beta-lactamase complex with SA4-44 inhibitor

3FV7 の概要

• エントリーDOI: 10.2210/pdb3fv7/pdb
• 分子名称: Beta-lactamase OXA-24, (2S)-2-[[2-methanoyl-7-(methoxycarbonylamino)indolizin-3-yl]amino]-3-methyl-3-sulfino-butanoic acid (3 entities in total)
• 機能のキーワード: b-lactamases, enzyme mechanism, carbapenem, inhibitors, hydrolase
• 由来する生物種: Acinetobacter baumannii
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 27984.06

構造登録者

Bou, G.,Santillana, E.,Sheri, A.,Beceiro, A.,Sampson, J.M.,Kalp, M.,Bethel, C.R.,Distler, A.M.,Drawz, S.M.,Pagadala, S.R.,Van den Akker, F.,Bonomo, R.A.,Romero, A.,Buynak, J.D. (登録日: 2009-01-15, 公開日: 2010-02-02, 最終更新日: 2023-11-22)

• 主引用文献: Bou, G.,Santillana, E.,Sheri, A.,Beceiro, A.,Sampson, J.M.,Kalp, M.,Bethel, C.R.,Distler, A.M.,Drawz, S.M.,Pagadala, S.R.,Van den Akker, F.,Bonomo, R.A.,Romero, A.,Buynak, J.D.; Design, synthesis, and crystal structures of 6-alkylidene-2'-substituted penicillanic acid sulfones as potent inhibitors of Acinetobacter baumannii OXA-24 carbapenemase.; J.Am.Chem.Soc., 132:13320-13331, 2010; PubMed: 20822105; DOI: 10.1021/ja104092z

実験手法

X-RAY DIFFRACTION (2 Å)