3FT2

Crystal Structure of a citrulline peptide variant of the minor histocompatibility peptide HA-1 in complex with HLA-A2

3FT2 の概要

• エントリーDOI: 10.2210/pdb3ft2/pdb
• 分子名称: HLA class I histocompatibility antigen, A-2 alpha chain, Beta-2-microglobulin, citrulline variant HA-1 peptide, ... (4 entities in total)
• 機能のキーワード: hla, human minor h antigens, antigen processing, antigen presentation, immune response, immunogenicity, membrane, mhc i, polymorphism, transmembrane, immunoglobulin domain, graft rejection, host-versus-graft disease, graft-versus-tumor immune system, immune system
• 由来する生物種: Homo sapiens (Human); 詳細
• 細胞内の位置: Membrane; Single-pass type I membrane protein: P01892; Secreted: P61769
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 44805.77

構造登録者

Reiser, J.-B.,Gras, S.,Chouquet, A.,Le Gorrec, M.,Spierings, E.,Goulmy, E.,Housset, D. (登録日: 2009-01-12, 公開日: 2009-04-28, 最終更新日: 2023-11-15)

• 主引用文献: Spierings, E.,Gras, S.,Reiser, J.B.,Mommaas, B.,Almekinders, M.,Kester, M.G.,Chouquet, A.,Le Gorrec, M.,Drijfhout, J.W.,Ossendorp, F.,Housset, D.,Goulmy, E.; Steric hindrance and fast dissociation explain the lack of immunogenicity of the minor histocompatibility HA-1Arg Null allele.; J.Immunol., 182:4809-4816, 2009; PubMed: 19342659; DOI: 10.4049/jimmunol.0803911

実験手法

X-RAY DIFFRACTION (1.8 Å)