3FPT

The Crystal Structure of the Complex between Evasin-1 and CCL3

3FPT の概要

• エントリーDOI: 10.2210/pdb3fpt/pdb
• 関連するPDBエントリー: 3FPU 3fpr
• 分子名称: Evasin-1, 2-acetamido-2-deoxy-beta-D-glucopyranose (3 entities in total)
• 機能のキーワード: novel fold, glycosylated protein, glycoprotein, secreted, immune system
• 由来する生物種: Rhipicephalus sanguineus (Brown dog tick)
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 35246.59

構造登録者

Shaw, J.P.,Dias, J.M. (登録日: 2009-01-06, 公開日: 2010-01-26, 最終更新日: 2024-10-30)

主引用文献

Dias, J.M.,Losberger, C.,Deruaz, M.,Power, C.A.,Proudfoot, A.E.I.,Shaw, J.P.
Structural basis of chemokine sequestration by a tick chemokine binding protein: the crystal structure of the complex between Evasin-1 and CCL3
Plos One, 4:-, 2009

PubMed Abstract: Chemokines are a subset of cytokines responsible for controlling the cellular migration of inflammatory cells through interaction with seven transmembrane G protein-coupled receptors. The blocking of a chemokine-receptor interaction results in a reduced inflammatory response, and represents a possible anti-inflammatory strategy, a strategy that is already employed by some virus and parasites. Anti-chemokine activity has been described in the extracts of tick salivary glands, and we have recently described the cloning and characterization of such chemokine binding proteins from the salivary glands, which we have named Evasins.

PubMed: 20041127
DOI: 10.1371/journal.pone.0008514

実験手法

X-RAY DIFFRACTION (2.7 Å)