3FO5

Human START domain of Acyl-coenzyme A thioesterase 11 (ACOT11)

Summary for 3FO5

• Entry DOI: 10.2210/pdb3fo5/pdb
• Descriptor: Thioesterase, adipose associated, isoform BFIT2, PENTAETHYLENE GLYCOL, CHLORIDE ION, ... (6 entities in total)
• Functional Keywords: orthogonal bundle, consortium, lipid transport
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 60191.24

Authors

Siponen, M.I.,Lehtio, L.,Arrowsmith, C.H.,Berglund, H.,Bountra, C.,Collins, R.,Dahlgren, L.G.,Edwards, A.M.,Flodin, S.,Flores, A.,Graslund, S.,Hammarstrom, M.,Johansson, A.,Johansson, I.,Karlberg, T.,Kotenyova, T.,Moche, M.,Nilsson, M.E.,Nordlund, P.,Nyman, T.,Persson, C.,Sagemark, J.,Thorsell, A.G.,Tresaugues, L.,Van-Den-Berg, S.,Weigelt, J.,Welin, M.,Wikstrom, M.,Wisniewska, M.,Shueler, H.,Structural Genomics Consortium (SGC) (deposition date: 2008-12-27, release date: 2009-02-24, Last modification date: 2024-03-20)

Primary citation

Thorsell, A.G.,Lee, W.H.,Persson, C.,Siponen, M.I.,Nilsson, M.,Busam, R.D.,Kotenyova, T.,Schuler, H.,Lehtio, L.
Comparative structural analysis of lipid binding START domains.
Plos One, 6:e19521-e19521, 2011

PubMed Abstract: Steroidogenic acute regulatory (StAR) protein related lipid transfer (START) domains are small globular modules that form a cavity where lipids and lipid hormones bind. These domains can transport ligands to facilitate lipid exchange between biological membranes, and they have been postulated to modulate the activity of other domains of the protein in response to ligand binding. More than a dozen human genes encode START domains, and several of them are implicated in a disease.

PubMed: 21738568
DOI: 10.1371/journal.pone.0019521

Experimental method

X-RAY DIFFRACTION (2 Å)