3FO5

Human START domain of Acyl-coenzyme A thioesterase 11 (ACOT11)

3FO5 の概要

• エントリーDOI: 10.2210/pdb3fo5/pdb
• 分子名称: Thioesterase, adipose associated, isoform BFIT2, PENTAETHYLENE GLYCOL, CHLORIDE ION, ... (6 entities in total)
• 機能のキーワード: orthogonal bundle, consortium, lipid transport
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 60191.24

構造登録者

Siponen, M.I.,Lehtio, L.,Arrowsmith, C.H.,Berglund, H.,Bountra, C.,Collins, R.,Dahlgren, L.G.,Edwards, A.M.,Flodin, S.,Flores, A.,Graslund, S.,Hammarstrom, M.,Johansson, A.,Johansson, I.,Karlberg, T.,Kotenyova, T.,Moche, M.,Nilsson, M.E.,Nordlund, P.,Nyman, T.,Persson, C.,Sagemark, J.,Thorsell, A.G.,Tresaugues, L.,Van-Den-Berg, S.,Weigelt, J.,Welin, M.,Wikstrom, M.,Wisniewska, M.,Shueler, H.,Structural Genomics Consortium (SGC) (登録日: 2008-12-27, 公開日: 2009-02-24, 最終更新日: 2024-03-20)

主引用文献

Thorsell, A.G.,Lee, W.H.,Persson, C.,Siponen, M.I.,Nilsson, M.,Busam, R.D.,Kotenyova, T.,Schuler, H.,Lehtio, L.
Comparative structural analysis of lipid binding START domains.
Plos One, 6:e19521-e19521, 2011

PubMed Abstract: Steroidogenic acute regulatory (StAR) protein related lipid transfer (START) domains are small globular modules that form a cavity where lipids and lipid hormones bind. These domains can transport ligands to facilitate lipid exchange between biological membranes, and they have been postulated to modulate the activity of other domains of the protein in response to ligand binding. More than a dozen human genes encode START domains, and several of them are implicated in a disease.

PubMed: 21738568
DOI: 10.1371/journal.pone.0019521

実験手法

X-RAY DIFFRACTION (2 Å)