3FMJ

P38 kinase crystal structure in complex with 4-(5-Methyl-3-phenyl-isoxazol-4-yl)-pyrimidin-2-ylamine

3FMJ の概要

• エントリーDOI: 10.2210/pdb3fmj/pdb
• 関連するPDBエントリー: 3FLN 3FLQ 3FLS 3FLW 3FLY 3FLZ 3FMH 3FMK
• 分子名称: Mitogen-activated protein kinase 14, 4-(5-methyl-3-phenylisoxazol-4-yl)pyrimidin-2-amine (3 entities in total)
• 機能のキーワード: p38; map kinase; serine/threonine kinase, atp-binding, kinase, nucleotide-binding, nucleus, phosphoprotein, serine/threonine-protein kinase, transferase, signaling protein
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 43000.99

構造登録者

Kuglstatter, A.,Ghate, M. (登録日: 2008-12-22, 公開日: 2009-12-22, 最終更新日: 2023-09-06)

• 主引用文献: Soth, M.,Kuglstatter, A.,Goldstein, D.; The Discovery of Pamapimod and R1487 as Orally Bioavailable and Highly Selective Inhibitors of p38 Map Kinase; To be Published,

実験手法

X-RAY DIFFRACTION (2 Å)