3FMH
P38 kinase crystal structure in complex with 6-(2,4-Difluoro-phenoxy)-8-methyl-2-((R)-1-methyl-2-tetrazol-2-yl-ethylamino)-8H-pyrido[2,3-d]pyrimidin-7-one
Summary for 3FMH
Entry DOI | 10.2210/pdb3fmh/pdb |
Related | 3FLN 3FLQ 3FLS 3FLW 3FLY 3FLZ 3FMJ 3FMK |
Descriptor | Mitogen-activated protein kinase 14, 6-(2,4-difluorophenoxy)-8-methyl-2-{[(1R)-1-methyl-2-(2H-tetrazol-2-yl)ethyl]amino}pyrido[2,3-d]pyrimidin-7(8H)-one (3 entities in total) |
Functional Keywords | p38; map kinase; serine/threonine kinase, atp-binding, kinase, nucleotide-binding, nucleus, phosphoprotein, serine/threonine-protein kinase, transferase, signaling protein |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 43163.08 |
Authors | Kuglstatter, A.,Ghate, M. (deposition date: 2008-12-22, release date: 2009-12-22, Last modification date: 2023-09-06) |
Primary citation | Soth, M.,Kuglstatter, A.,Goldstein, D. The Discovery of Pamapimod and R1487 as Orally Bioavailable and Highly Selective Inhibitors of p38 Map Kinase To be Published, |
Experimental method |
Structure validation
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