3FLZ

P38 kinase crystal structure in complex WITH 8-Methyl-6-phenoxy-2-(tetrahydro-pyran-4-ylamino)-8H-pyrido[2,3-d]pyrimidin-7-one

3FLZ の概要

• エントリーDOI: 10.2210/pdb3flz/pdb
• 関連するPDBエントリー: 3FLN 3FLQ 3FLS 3FLW 3FLY 3FMH 3FMJ 3FMK
• 分子名称: Mitogen-activated protein kinase 14, 8-methyl-6-phenoxy-2-(tetrahydro-2H-pyran-4-ylamino)pyrido[2,3-d]pyrimidin-7(8H)-one (3 entities in total)
• 機能のキーワード: p38; map kinase; serine/threonine kinase, atp-binding, kinase, nucleotide-binding, nucleus, phosphoprotein, serine/threonine-protein kinase, transferase, signaling protein
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 43101.10

構造登録者

Kuglstatter, A.,Ghate, M. (登録日: 2008-12-19, 公開日: 2009-12-22, 最終更新日: 2023-09-06)

• 主引用文献: Soth, M.,Kuglstatter, A.,Goldstein, D.; The Discovery of Pamapimod and R1487 as Orally Bioavailable and Highly Selective Inhibitors of p38 Map Kinase; To be Published,

実験手法

X-RAY DIFFRACTION (2.23 Å)